Acrylics and other plastics are generally very easy to work with (with the exception of ones containing vinyl - see below).
Working with plastics can be potentially hazardous if the wrong type of plastic is used. Additional safety considerations include:
Remember, it is up to the discretion of the makerspace staff as to whether or not it is safe to use any material in the laser cutter.
Different types of plastics react very differently when heated with a laser. Many lighten, however others do not change color at all (though part of the top layer will still be removed). If possible, test your designs on a spare piece, or an inconspicuous part of the material. You can also research the plastic through a simple internet search to see if other people have tried it.
Some plastics, such as acrylics, react negatively to ammonia-based cleaners. Make sure any cleaner used will not damage or discolor the material.
Try to cut through the plastic in a single pass. If the laser does not go all the way through the material, often times the melted plastic will pool in to the gap created by the laser and re-solidify.
Unlike wood, plastics generally do not change color along the edges when cut. However, they are prone to warping if the power is too high or the speed is too slow. For best results, try to determine the minimum amount of power needed to cut through at a high speed.